Major Rune of Infiltration

• (1): +1% damage against foes with less than 50% health.
• (2): +21 Precision
• (3): +2% damage against foes with less than 50% health.
• (4): +39 Precision

Major Rune of Melandru

• (1): +15 Toughness
• (2): +21 Vitality
• (3): +30 Toughness
• (4): -6% Incoming Condition Duration; -6% Incoming Stun Duration

Superior Rune of Dwayna

• (1): +25 Healing
• (2): +10% Regeneration Duration
• (3): +50 Healing
• (4): 25% chance when struck to gain regeneration for 10 seconds. (Cooldown: 45s)
• (5): +100 Healing
• (6): +20% regeneration duration; when you use a heal skill, you and all nearby allies gain regeneration for 5 seconds. (Cooldown: 10s)

Superior Rune of Hoelbrak

• (1): +25 Power
• (2): +10% Might Duration
• (3): +50 Power
• (4): 25% chance when struck to gain might for 10s. (Cooldown: 5s)
• (5): +100 Power
• (6): +20% might duration; -20% condition duration applied to you.

Major Rune of the Grove

• (1): +15 Healing
• (2): +6% Protection Duration
• (3): +30 Healing
• (4): 15% chance when struck to gain protection for 4 seconds. (Cooldown: 30s)

Major Rune of the Flame Legion

• (1): +15 Power
• (2): +6% Burning Duration
• (3): +30 Power
• (4): 15% chance to cause burning for 1 second when hit. (Cooldown: 10s)

Major Rune of the Eagle

• (1): +15 Precision
• (2): +21 Ferocity
• (3): +30 Precision
• (4): +39 Ferocity

Major Rune of Scavenging

• (1): +15 Condition Damage
• (2): 15% chance when struck to cause your next attack to steal life. (Cooldown: 25s)
• (3): +30 Condition Damage
• (4): After using your healing skill, your next attack skill steals health. (Cooldown: 10s)

Major Rune of the Lich

• (1): +15 Vitality
• (2): +3% Condition Duration
• (3): +30 Vitality
• (4): +6% Condition Duration

Major Rune of the Centaur

• (1): +15 Power
• (2): +6% Swiftness Duration
• (3): +30 Power
• (4): -30% Incoming Cripple Duration.

Major Rune of Grenth

• (1): +15 Condition Damage
• (2): +6% Chill Duration
• (3): +30 Condition Damage
• (4): 15% chance when struck to cause chill for 3 seconds. (Cooldown: 30s)

Major Rune of Rage

• (1): +15 Ferocity
• (2): +6% Fury Duration
• (3): +30 Ferocity
• (4): 15% chance when struck to gain fury for 15 seconds. (Cooldown: 30s)

Major Rune of Balthazar

• (1): +15 Condition Damage
• (2): +6% Burning Duration
• (3): +30 Condition Damage
• (4): +9% burning duration; when you're struck below 20% health gain quickness for 5 seconds. (Cooldown: 90s)

Major Rune of Lyssa

• (1): +15 Precision
• (2): +3% Condition Duration
• (3): +30 Precision
• (4): When you use a heal skill you gain a random boon for 6 seconds. (Cooldown: 10s)

Superior Rune of the Afflicted

• (1): +25 Condition Damage
• (2): +10% Bleeding Duration
• (3): +50 Condition Damage
• (4): +15% Poison Duration
• (5): +100 Condition Damage
• (6): +20% bleeding duration; when you are downed, you create a death nova. (Cooldown: 30s)

Major Rune of Melandru

• (1): +15 Toughness
• (2): +21 Vitality
• (3): +30 Toughness
• (4): -6% Incoming Condition Duration; -6% Incoming Stun Duration

Major Rune of the Pack

• (1): +15 Power
• (2): +6% Swiftness Duration
• (3): +30 Power
• (4): 15% chance when struck to grant nearby allies might, fury, and swiftness for 10s . (Cooldown: 20s)

Major Rune of the Eagle

• (1): +15 Precision
• (2): +21 Ferocity
• (3): +30 Precision
• (4): +39 Ferocity

Major Rune of the Centaur

• (1): +15 Power
• (2): +6% Swiftness Duration
• (3): +30 Power
• (4): -30% Incoming Cripple Duration.

Major Rune of Hoelbrak

• (1): +15 Power
• (2): +6% Might Duration
• (3): +30 Power
• (4): 15% chance when struck to gain might for 10 seconds. (Cooldown: 5s)

Major Rune of the Traveler

• (1): +5 to all stats
• (2): +3% Boon Duration
• (3): +7 to All Stats
• (4): +6% Boon Duration; +6% Condition Duration